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As Karl Barth put it, the joy that Paul describes is a defiant "nevertheless," which draws strength from the gospel story and from laying one's deepest concerns before God "with thanksgiving." This joy seems to take root even in darkness. It is encouraged by the spread of the gospel, the growth of a young church, but most of all by the deep joy of God's presence and the hope this gives for whatever the future may hold.
-- William Dyrness
I do like that word, "nevertheless". It could well be a mantra for us whenever we are in times of great difficulty.